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Abeta oligomers & Alzheimer's disease

Structure of Abeta oligomers involved in Alzheimer's disease

Structure of Abeta oligomers involved in Alzheimer's disease


Small oligomers of amyloid-beta (Abeta) peptide are believed to initiate Alzheimer's disease, but their fleeting nature makes their structures elusive. We combined fast fluorescence and slow solid-state NMR spectroscopies to probe these bio-active Abeta oligomers. Their structure substantially differs from the less-toxic mature fibrils only in two specific regions. Interestingly, 10 of 11 known disease-causing Abeta mutations occur in these two regions. Our results provide atomic-level structural markers for developing potential Alzheimer therapeutics. More details in Sarkar et al., Angew. Chem. Int. Ed., Volume 53, Issue 27, July 1, 2014, Pages: 6888 6892 (from the labs of S. Maiti and P. K. Madhu)

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